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Dr. Haim I. Bicher (Haim Bicher, M.D.)last publish paper:

Haim Bicher, President of Valley Cancer Institute. Dr. Haim Bicher received an award in India.

Dr. Haim I. Bicher (James I. Bicher, Haim Bicher, M.D.), founder of Valley Cancer institute, recently published a very advance (for it's time) paper, in the Deutsche Zeitschrift für Onkologie (German Journal of Oncology)

Haim Bicher, President of Valley Cancer Institute. Dr. Haim Bicher received an award in India.

Dr. Haim I. Bicher  (Haim Bicher, M.D.), President of Valley Cancer Institute, receives an award at the

XXVIII International Clinical Hyperthermia Society,

Mumbai, India.
Paper published in the Radiology Journal, November 1980

The Physiological Effects of Hyperthermia

 Haim I. Bicher, M.D.

 In the application of hyperthermia to control cancer, physiological factors such as Ph, Ph2, and blood flow must be documented in vivo at normal and elevated temperatures for both the tumor and its normal host tissue. The present symposium was arranged to gather recent research done in this area and to expose the problems inherent in these efforts.

  HYPERTHERMIA is currently being employed in clinical trials to control cancer.  The protocols in these trials employ hyperthermia either as the only treatment modality or in combination with other accepted modalities such as radiation therapy and chemotherapy.

            The current interest in hyperthermia is prompted mainly by some very interesting radiobiological observations made at the cellular level.  In vitro studies (1-4) demonstrate that heat – induced lethal damage to cells in culture follows a quasi threshold exponential response similar in shape to cell survival curves obtained for ionizing radiation exposure or treatment with some cytotoxic agents.  Different cell lines exhibit widely different    thermal sensitivities (2, 3). Heat survival curves at 45.5’C For aerobic and hypoxic cells are more heat sensitive than well oxygenated cells (5).  Similar observations were made by Schulman and Hall (6) for V79 Chinese hamster cells and by Kim et al. (7) for Hela cells. Assuming that the W138VA  13/2  RA cells model the malignant cells of a human tumor and  W138 cells model the associated normal tissue, Kase and Hahn (8) observed  that the transformed cells are more readily  destroyed by hyperthermia .     Others (9-13) have also reported that tumor cells are more hermosensitive than normal cells. Just as In the case of ionizing radiation, the response to hyperthermia is also dependent on the phase of the cell cycle during exposure.  However, mid-to-late S-phase cells, which are the most resistant to ionizing radiation, are the most sensitive to hyperthermia (4, 12, 14). Gerweck (15, 16) has clearly demonstrated that the lethal response of CHO cells to hyperthermia (41-44’C) increase as pH is reduced from 7.6 to 6.7. Hahn (17) has shown that when cells are heated in a salt solution lacking nutrients instead of in a complete medium, thermal sensitivity increases greatly. Another aspect of hyperthermia which may have a great impact on its success is the resistance of cells to subsequent heat treatments. The phenomenon is termed thermotolerance. From studies with mammalian cells in culture (18, 19) it was observed that there is an increase in Do of a subsequent hyperthermia survival curve. Thermotolerance is induced during a 3-5 hour incubation period at near physiological temperatures after heating for a short time at temperatures greater than 43’C (20, 21).

    I       n vitro studies (7, 10, 22, 23) also have demonstrated that hyperthermia combined with ionizing radiation has a synergistic cell killing effect.  The importance of the sequence in which heat an radiation are applied has been studied in detail by Sapareto et  al. (22) The synergistic effect is most pronounced for radioresistant  S-phase cells (22,24). There are no in vitro data indicating differential sensitization of cancer cells as apposed to normal tissue cells.

In the recent literature (26-38), several investigators have achieved local tumor control using hyperthermia either alone or in combination with irradiation.  Crile (26) studied the effectiveness of hyperthermia and the dependence of cure on the temperature achieved and the length of the treatment period on mouse sarcoma. He also demonstrated the effectiveness of the combination of heat and radiation in the treatment of cancer of the rectum (27). Hartman and Crile (28) applied hyperthermia in the treatment of human osteogenic sarcoma with good results. Cavaliere et al. (29) and Morica et al. (30) documented the effect of heat on tumor cells in rats and the sparing of normal tissues. Other investigators (31, 32) had similar data showing normal tissue sparing with the

combined modalities. Recent clinical reports (33-38) clearly demonstrate that hyperthermia, particularly in combination with irradiation; can prove to be a very useful modality in the treatment of cancer.

In vivo results do not always agree with the in the in vitro results, when combining hyperthermia and irradiation. The in vitro results indicate that, with heating time adjusted to achieve the same killing from heat alone at various temperatures, a decrease in temperature increases the relative killing from the interaction of radiation and heat. This is in contradiction to the in vivo results (25) which indicate that the apposite should occur.

            In order to fully make use of in vitro observations made under controlled conditions in the application of hyperthermia to cancer control, the physiological factors such as Ph, oxygen consumption, nutrients, and flow of both tumor and normal host tissue should be measured in vivo. Furthermore, these factors should be documented not only at normal temperatures but also under hyperthermic conditions. Under certain conditions a selective destruction of tumor tissue might be possible with normal tissue sparing, For example, several studies (39-42) indicate that pH of fluid in human and rodent solid tumors is lower than the normal tissue pH of 7.4. Paramount among the other factors which may change and subsequently influence the response of cells or tissues to supranormal  temperatures are the vascular changes, blood flow response and the net result of this on tissue oxygenation. The last factor may change the affect of both hyperthermia and radiation therapy when used in combination. Insufficient information is available on the temperature modifications of tumor blood supply, tumor oxygen tension and consumption and respiratory gas exchange by malignant cells in vivo. This symposium on the physiological effects of hyperthermia was arranged in order to assemble recent research on the physiological response of normal and tumor tissue to hyperthermia. 

                                                                

 Radiology, Division of Radiation Biology and Physics (H.I.B., Division Head), Henry Ford Hospital, Detroit, MI 48202. Submitted for publication 5 April 1980;

 

 Presented at the Hyperthermia Microcirculation Symposium conducted by the Radiation Therapy Oncology Group under the sponsorship of the National Institutes of Health, Albuquerque, NM   January 1980.  See also the following articles by Eddy  (p.515) and Bicher (p.523) in this issue. The remainder of the Symposium will be published in the December 1980 issue of Radiology.

INDEX TERMS: Blood, flow dynamics. Hyperthermia. Oxygen.

 Radiology 137:511-513, November 1980

 
 
 

Haim Bicher, President of

CURRICULUM VITAE

 

JAMES (HAIM) I. BICHER, M.D.

PERSONAL DATA

Born: San Cristobal, Santa Fe, Argentina, May 12, 1937.

Nationality: U.S. Citizen.

SCHOLASTIC Haim ISTORY

M.D. Hadassah Medical School, Jerusalem, Israel. 1962

University of Buenos Aires Medical School 1954-1956

POST GRADUATE EDUCATION

Residency, Radiation Therapy 1976-1977

Roswell Park Memorial Institute

Buffalo, New York

Residency, Radiation Therapy 1974-1976

University of Arkansas for Medical Sciences

Little Rock, Arkansas

InternsHaim Ip 1962

Beilinson Hospital

Petah-Tiqya, Israel

 

LICENSURE

ABR Certification in Radiation Therapy 1977

California Medical License 1981

MicHaim Igan Medical License 1978

New York Medical License 1977

Arkansas Medical License 1976

Arkansas Healing Arts Certificate 1975

FLEX Approve1975

ECFMG Approved - 1961

 

APPOINTMENTS

 

Senior Consultant 1991 to present

Beritashvili Institute of Physiology

Georgian Academy of Sciences

Republic of Georgia, USSR

Director, Valley Cancer Institute 1985 to present

12099 W. WasHaim Ington Blvd., Suite 304

Los Angeles, California

CHaim Ief, Hyperthermic Clinic 1982 to 1985

Western Tumor Medical Group

Van Nuys, California

Director, Non-Ionizing Radiation 1978 to 1981

Cancer Treatment Center

Henry Ford Hospital

Detroit, MicHaim Igan

 

Associate CHaim Ief 1977 to 1978

Department of Radiation Medicine

Roswell Park Memorial Institute

Buffalo, New York

 

Associate Professor Pharmacology 1973 to 1976

University of Arkansas for Medical Sciences

Little Rock, Arkansas

Associate Professor of Anatomy 1971 to 1973

and Research Medicine

Medical University of South Carolina

Charleston, South Carolina

Assistant Professor of Anatomy 1969 to 1971

Medical University of South Carolina

Charleston, South Carolina

Associate in Anatomy 1968 to 1969

Medical University of South Carolina

Charleston, South Carolina

Senior Scientist 1962 to 1968

Rogoff Medical Research Institute

Beilinson Hospital

Israel

Research Supervisor 1962 to 1968

Pharmacological Screening Program

Lecturer in Physiology and Pharmacology 1962 to 1968

Tel Aviv University, Israel

 

HONORS

Member of National Committee on Hyperthermia.

Founder and Past President of the North American Hyperthermia Group (NAHG).

Travel Award, 6th International Congress of Radiation Research, 1979.

Secretary and (1972-1981) President (1981) of International Society of Oxygen Transport of Tissue.

Zondec Award (Hadassah Medical School, Jerusalem), 1962.

President and Founder of the American Society of Clinical Hyperthermic Oncology (ASCHO).

 

ACADEMIC APPOINTMENTS

 

Clinical Associate Professor in Radiology 1977-1978

State University of New York (SUNY)

Associate Professor 1978-1982

Department of Biology

Wayne State University - Detroit, MicHaim Igan

 

SPECIALIZATION TRIPS

Six (6) months - Institute of Pharmacology 1964-1965

Bonn University (Prof. R. Domenjoz)

 

PROFESSIONAL REVIEWER OR EDITORIAL APPOINTMENTS

 

Reviewer for RADIOLOGY and MICROVASCULAR RESEARCH 1980

Reviewer for RADIOLOGY and MICROVASCULAR RESEARCH 1979

Reviewer for RADIOLOGY and MICROVASCULAR RESEARCH 1978

Editorial Board of NEUROLOGICAL SCIENCES 1977

Editorial Board of MICROVASCULAR RESEARCH 1976

Reviewer for NATIONAL SCIENCE FOUNDATION 1976

Associate Editor of ENDOCURIETHERAPIE/HYPERTHERMIC 1985

ONCOLOGY - An International Journal

PROFESSIONAL CONSULTANTSHaim IPS

Mediscience Technology, Inc. 1971-1975

Kabi-Stockholm 1971-1972

Transidyne General Corporation 1969-1971

Schering Corporation 1965-1971

Bristol Laboratories 1965-1971

PATENTS

3832994 Cardiac Monitor

365431 Catheter System for Blood Gas Monitoring

392065 CardiograpHaim Ic Signal Processing

370048 Blood Cell Aggregometer

433260 External Microwave Applicator and Method

160217 Microwave Antenna System for Intracavitary Insertion

4369795 Implantable Microthermocouple Member

 

PROFESSIONAL SOCIETIES

American Society of Therapeutic radiologists (ASTR)

James Haim Bicher MD, James Haim Bicher MD

American Microcirculatory Society

James Haim Bicher MD, James Haim Bicher MD

European Society of Microcirculation

James Haim Bicher MD, James Haim Bicher MD

International Society on Oxygen Transport of Tissue (Past President)

James Haim Bicher MD, James Haim Bicher MD

North American Hyperthermia Group (Founder and Past President) (Currently "Society For Thermal Medicine")

James Haim Bicher MD, James Haim Bicher MD

European Society of Hyperthermic Oncology(ESHO) (Founding Member)

James Haim Bicher MD, James Haim Bicher MD

Radiation Research Society

James Haim Bicher MD, James Haim Bicher MD

Western Hyperthermia Group (Founder)

James Haim Bicher MD, James Haim Bicher MD

American Society of Clinical Hyperthermic Oncology (Founder and President from 1985-1986)

International Clinical Hyperthermia Society (ICHS) Founder member and past president (1999)

Current board member and American Vice-President

James Haim Bicher MD, James Haim Bicher MD

PUBLISHED BOOKS

James Haim Bicher MD, James Haim Bicher MD

1. James Haim Bicher. Blood Cell Aggregation in Thrombic Processes. Ed. W Seegers, Charles C Thomas, Springfield, 1972.

James Haim Bicher MD, James Haim Bicher MD

2. James Haim Bicher, Bruley DF, (eds). Oxygen Transport to Tissue: Instrumentation, Methods and Physiology. Plenum Press, New York, 1973.

James Haim Bicher MD, James Haim Bicher MD

3. Bruley DF, James Haim Bicher, (eds). Oxygen Transport to Tissue: Pharmacology, Mathematical Studies and Neonatology. Plenum Press, New York, 1973.

James Haim Bicher MD, James Haim Bicher MD

4. Silver I, James Haim Bicher, Eherecinska M, (eds). Oxygen Transport to Tissue: III. Plenum Press, New York, 1978.

James Haim Bicher MD, James Haim Bicher MD

5. James Haim Bicher, Bruley DF. Hyperthermia. Plenum Press, New York, 1982.

James Haim Bicher MD, James Haim Bicher MD

6. James Haim Bicher, Bruley DF. Oxygen Transport to Tissue: IV. Plenum Press, New York, 1983.

James Haim Bicher MD, James Haim Bicher MD

7. Bruley DF, Reneau DD, James Haim Bicher. Oxygen Transport to Tissue: VII. Plenum Press, New York, 1984.

James Haim Bicher MD, James Haim Bicher MD

8. James Haim Bicher, McLaren JR, Pigliucci GM, (eds). Consensus on Hyperthermia for the 1990s. Clinical Practice in Cancer Treatment. Plenum Press, New York and London, 1990.

James Haim Bicher MD, James Haim Bicher MD

James Haim Bicher MD, James Haim Bicher MD

PUBLISHED BOOK CHAPTERS

James Haim Bicher MD, James Haim Bicher MD

1. James Haim Bicher, Hetzel FW, Sandhu TS. Physiology and Morphology of Tumor Microcirculation on Hyperthermia. Chapter 9. Ed. K Storm, K Hall Publisher, New York, 1982.

James Haim Bicher MD, James Haim Bicher MD

2. James Haim Bicher, Hetzel FW, Sandhu TS. Thermoradiotherapy in Hyperthermia. Ed. K Storm. K Hall Publisher, New York, 1982.

James Haim Bicher MD, James Haim Bicher MD

 

PUBLICATIONS

1. Weiman J, James Haim Bicher, Levi D. Application of photoconductive cell to the study of peripheral circulation in limbs of animals and men. J. Appl Physiol 1960, 15:317.

2. James Haim Bicher. Description and mechanism of photoplestimograpHaim Ic respiratory wave in the cat. M.D. Thesis, Jerusalem, 1961.

3. James Haim Bicher. A simple method for determination of systolic blood pressure in frogs. J Apl Physiol 1962, 17:173.

4. James Haim Bicher, Gitter S, Manoach M, Rosen M, De Vries A. Neurotoxic activity of Vipera palestinae venom, depression of central and cortical autonomic vasoregulatory mechanism. Bulletin Res Council of Israel, Section F. Exp Med 1963;10:34 (Abstract).

5. James Haim Bicher, Roth M, Gitter S. The influence of Vipera palestinae neurotoxin and of cobra venom on vegetative function in cats and on isolated nerve preparation. Israel J. Exp Med 1963, 11:206.

6. James Haim Bicher, Klibansky H, SHaim Iloach J, De Vries A, Gitter S. Pharmacological effects of electrophoretically separated fractions of Naja naja venom. Proc Israel Physiol and Pharmacol Soc 1965; 1:22 (Abstract).

7. James Haim Bicher. Intravascular red cell aggregation (sludge) as a factor in the experimental induction of myocardial damage. Proc. Israel Physiol and Pharmacol Soc. 1965, 1:53 (Abstract).

8. Krupnik J, James Haim Bicher, Gitter S. Neurotoxic effects of cobra venom. Proc of the Israel Physiol and Pharmacol Soc 1965, 7:429.

9. Wins M, James Haim Bicher, Steinitz J, Rosefeld J, Gitter S. Hypopotassemia induced by intravenous administration of barium chloride. Israel J. Med Sci 1965, 1:154.

10. James Haim Bicher, Gitter s, Rosen M. On the mechanism of Vipera palestinae venom induced shock. Bibl Anat 1965, 7:429.

11. James Haim Bicher, Klibansky H, SHaim Illoach J, Gitter S, De Vries A. Isolation of three different neurotoxins from India cobra (Naja naja) venom and the relation of their action to phospholiphase. A. Biochem Pharmacol 1965, 14:1779.

12. Roth M, James Haim Bicher, Gitter S. The action of Indian cobra (Naja naja) venom and its neurotoxic fractions on nerve membrane. Proc Israel and Pharmacol Soc 1966, 2:34 (Abstract).

13. James Haim Bicher. Specific sites of action of snake venom in the central nervous system. International Symposium on Animal Venoms, Sao Paulo, Brazil, 1966; pg. 86 (Abstract).

14. James Haim Bicher, Krupnik J, Eliash S. Pharmacological properties of 1-6 tetrahydrocannabinol. III International Pharmacological Congress, Sao Paulo, Brazil 1966; pg. 145 (Abstract).

15. James Haim Bicher, Beemer AM. Sludge as a factor producing cardiac ischemia in atherosclerotic rabbits. Proc Israel Physiol and Pharmacol Soc 1966;2:35 (Abstract).

16. James Haim Bicher, Roth M, Gitter S. Neurotoxic activity of Vipera palestinae venom - depression of central autonomic vasoregulatory mechanism. Med et Pharmacol Exp 1966, 14:349.

17. James Haim Bicher. Specific sites of action of snake venoms in the central nervous system. Mem Inst Butantan Simp Internac 1966; 32: 532.

18. James Haim Bicher, Beemer AM. The role of sludge in production of experimental ischemic myocardial damage. Bibl Anatomica 1967; 9: 16. (Proc 4th Europ. Conf. Microcirculation. Harders H (ed) Basel: S Karger, 1966).

19. James Haim Bicher, Beemer AM. Induction of ischemic myocardial damage by red cell aggregation (sludge) in the rabbit. J Atherosclerosis Res 1967, 7:409.

20. James Haim Bicher. Prevention of sludge induced myocardial damage by anti-adhesive drug. Proc V Int Conf on Microcirculation, Gothenburg, 1968 (Abstract).

21. James Haim Bicher, Licht A. K and the platelet membrane relationsHaim Ip to platelet aggregation and its prevention by anit-adhesive drugs. Proc of the Internat Union of Physiol Sciences, VII, 44, 1968.

22. James Haim Bicher. Effects of adrenalin infusion on platelet aggregation in the cat as determined by using the screen filtration pressure method. Proc Southern Soc of Anatomists, 1968 (Abstract).

23. James Haim Bicher, Meshulam R. Pharmacological effects of two active constituents of marihuana. Arch Int Pharmacodyn 1968, 172:24.

24. Krupnik J, James Haim Bicher, Gitter S. Central neurotoxic effects of the venoms of Naja naja and Vipera palestinae. Toxicon 1968, 6:11.

25. James Haim Bicher. Prevention by an anti-adhesive drug of lung thrombosis caused by blood cell aggregation. Anat Rec 1968, 163:2.

26. James Haim Bicher, Licht A. The effect of adrenalin infusion of platelet aggregation in the cat as determined using the screen filtration pressure method. Pharmacol 1969, 2:209.

27. James Haim Bicher. A current concept of thrombosis. Symp on Bioengineering. 157th meeting of the Am Chem Soc, Minneapolis, 1969.

28. James Haim Bicher. 2-Methyl-2 tert butyl-ketolactone, a prototype anti-thrombic drug preventing platelet and red cell aggregation. Circ Res 1969, 39-49, Suppl. III:2.

29. James Haim Bicher. Prevention of sludge induced myocardial damage by an anti-adhesive drug. Bibl Anat 1969, 10:202.

30. Nuriel EH, James Haim Bicher, Veanderlns E. The influence of various colloids on blood cell aggregation in vivo, as determined by the screen filtration pressure method. Biorrheology 1969, 6:65.

31. James Haim Bicher, Knisely MH. Effect of circulation changes on cerebral oxygenation as determined with a new ultramicro oxygen electrode. Fred Proc 1970, 29:2 (Abstract).

32. James Haim Bicher. The "membrane capacitance" aggregometer. A new method able to detect platelet aggregation in whole blood. Proc VI Conf on Microcirculation. Aalborg, Denmark 1970, 137:(Abstract).

33. Ogilvie RW, James Haim Bicher. In vivo demonstration of several of a dextran induced sludge. Proc of VI Conf on Microcirculation. Aalborg, Denmark, 1970, 162 (Abstract).

34. Reneau DD, Bruley DF, James Haim Bicher, Knisely MH. A mathematical simulation of the simultaneous difussion of oxygen and glucose in the capillaries and tissues of the human brain. Proc VI International Conf on Microcirculation. Aalborg, Denmark, 1970, 165 (Abstract).

35. James Haim Bicher, Knisely MH. Brain tissue reoxygenation time, demonstrated with a new ultramicro oxygen electrode. J Appl Physiol 1970; 28:387-390.

36. James Haim Bicher. Anti-thrombic effect of a heparin like substance (SP 54) preventing red cell and platelet aggregation. Arznelmittelforschung (Drug Research) 1970, 20:379.

37. James Haim Bicher, Reneau DD, Knisely MH. Brain tissue oxygenation as determined with a new ultramicro oxygen electrode. Hershey D (ed). Blood oxygenation. New York: Plenum Press, 1970, 201- 217.

38. Reneau DD, James Haim Bicher, Knisely MH. A mathematical analysis predicting cerebral tissue reoxygenation time as a function of the rate of change of effective cerebral blood flow. Hershey D (ed). Blood Oxygenation. New York: Plenum Press, 1970, 175- 200.

39. James Haim Bicher. 2-methyl-2-tert butyl-ketolactone, an anti-adhesive drug preventing platelet and red cell aggregation. Pharmacol 1970, 4:152.

40. James Haim Bicher. A concept of anti-thrombic therapy based on the pharmacological effects of drugs preventing platelet and red cell aggregation. Proc of the Second International Symposium on Artherosclerosis. Jones R (ed). New York: Springer-Verlag, 1970, 538.

41. Levi J, James Haim Bicher, Rozenfeld JB. Platelet aggregation in several cardiovascular diseases determined with a modified screen filtration pressure method. J Med 1970, 1:132.

42. James Haim Bicher. Anti-adhesive drugs in thrombosis. Throm et Diath Haem 1970; suppl 42:197.

43. James Haim Bicher. Reneau DD, Bruley DF, Knisely MH. Changes in brain tissue oxygenation during acute hypoglycemia as determined with oxygen ultramicro electrode and on-line computer simulation. Proc of Internat Union of Physiological Sciences, Vol. IX, 1971 (Abstract).

44. James Haim Bicher, Beemer A. Prevention by anti-adhesive drug of thrombosis caused by blood cell aggregation. Angiol 1971, 21:413.

45. Reneau DD, Reardon WR, James Haim Bicher, Bruley DF, Knisely MH. On line computer simulation of oxygen response in brain during anoxic-anoxia and hypoglycemia. Biomedical Engineering-Computer Simulation Symposium. Am I Ch E J 1970; 20.

46. James Haim Bicher. The "membrane capacitance" aggregometer. A method for measuring platelet aggregation in whole blood. Angiol 1971, 22:285.

47. James Haim Bicher, Bruley DF, Reneau DD, Knisely MH. Effect of intravascular red cell aggregation and its counteraction by anti- adhesive drugs on brain tissue oxygenation. Proc 6th Europ Conf Microcirculation. Ditzel J, Lewis DH (eds). Basel: S Karger, 1971, 193.

48. James Haim Bicher, Reneau DD, Bruley DF, Knisely MH. Effect of microcirculation changes on brain tissue oxygenation. J Physiol 1971, 217:689.

49. Dougherty W, James Haim Bicher. The effects of anti-adhesive agents on the ultrastructure of rabbit blood platelets in vivo. Throm Diath Haem 1971; XXVI, 2:378.

50. James Haim Bicher, Fitts CT, Yarbrough DY. Effect of norepinephrine, blood sludging and respiratory gas change on blood and tissue oxygenation as determined with ultramicro oxygen electrodes. Surg Forum 1971, 22:213.

51. Reneau DD, Knisely MH, James Haim Bicher, Bruley DF. Glucose diffusion and consumption in the human brain, Part I: Literature review and mathematical development. Transport Processes in Biology and Medicine, 70th National Meeting of AIChE. Atlantic City, NJ, 1971.

52. Reneau DD, Knisely MH, James Haim Bicher, Bruley DF. Glucose diffusion and consumption in the human brain, Part II: A steady-state mathematical simulation of glucose transport in cerebral cortex. Transport Processes in Biology and Medicine, 70th National Meeting of AIChE. Atlantic City, NJ, 1971.

53. Bruley DF, Reneau DD, James Haim Bicher, Knisely MH. Modeling cerebral tissue oxygenation. Proc Workshop on Oxygen Transport in Tissue. Dortmund, Germany, 1971.

54. Bruley DF, James Haim Bicher, Reneau DD, Knisely MH. Autoregulatory phenomena related to cerebral tissue oxygenation. Chemical Engineering Progress. Symposium Series, 1971, 67:195.

55. James Haim Bicher, Ohki S. Intracellular pH electrode; experiments on the giant squid axon. BiocHaim Im et Biophysica Acta 1972, 255:900.

56. Malcolm R, James Haim Bicher, Duncan RC, Knisely MH. Behavioral effects of erythrocyte aggregation. Microvascular Res 1972, 4:94.

57. McCracken A, Bruley DF, Reneau DD, James Haim Bicher, Knisely MH. A systems analysis for the simultaneous diffusion of oxygen, carbon dioxide, and glucose in the capillaries and tissues of the human brain. Transactions of the First Pacific Chemical Engineering Congress. Kyoto, Japan, 1972, 137.

58. Reneau DD, Bruley DF, James Haim Bicher, Knisely MH. Simultaneous diffusion of oxygen and glucose in brain. Transactions of the First Pacific Chemical Engineering Congress. Kyoto, Japan, 1972, 132.

59. Bruley DF, Reneau DD, James Haim Bicher, Knisely MH. Studies of cerebral tissue oxygenation and related auto-regulation. Advances in Chemistry Series, No. 118, Chem Engineering in Medicine 1973, 290.

60. James Haim Bicher, Reneau DD, Bruley DF, Knisely MH. Brain oxygen supply and neuronal activity under normal and hypoglycemic conditions. Am J. Physiol 1973, 224:275-282.

61. Reneau DD, James Haim Bicher, Bruley DF, Knisely MH. On line computer simulation of oxygen response in brain during anoxic anoxia. Kessler M, et al (eds). Oxygen Supply. Munchen: Urban e Schwarzenberg, 1973, 40.

62. James Haim Bicher, Bruley DF, Reneau DD, Knisely MH. Regulatory mechanisms of brain oxygen supply. Kessler M, et al (eds). Oxygen Supply. Munchen: Urban e Schwarzenberg, 1973, 181.

63. Bruley DF, Reneau DD, James Haim Bicher, Knisely MH. Modeling cerebral tissue oxygenation with autoregulation. Kessler M, et al (eds). Oxygen Supply. Munchen: Urban e Schwarzenberg, 1973, 30.

64. James Haim Bicher. Autoregulation of oxygen supply to brain tissue. James Haim Bicher, Bruley DF (eds). Oxygen Transport to Tissue: Instrumentation, methods and physiology. New York: Plenum Press, 1973, 215.

65. James Haim Bicher, Bruley DF, Knisely MH. Anti-adhesive drugs and tissue oxygenation. Bruley DF, James Haim Bicher (eds). Oxygen Transport to Tissue: Pharmacology, mathematical studies and neonatology. New York: Plenum Press, 1973, 657-660.

66. James Haim Bicher, Rubin JW, Adams R. Clinical use of a new intra- arterial catheter electrode system. Bruley DF, James Haim Bicher (eds). Oxygen transport to tissue: instrumentation, methods, and physiology. New York: Plenum Press, 1973, 107-112.

67. Hunt DH, Bruley DF, James Haim Bicher, Knisely MH. Distributed model solution techniques for capillary tissue systems. Bruley DF, James Haim Bicher (eds). Oxygen transport to tissue: pharmacology, mathematical studies and neonatology. New York: Plenum Press, 1973, 887-891.

68. Bruley DF, Hunt DH, James Haim Bicher, Knisely MH. Simulating myocardium oxygen dynamics. Bruley DF, James Haim Bicher (eds). Oxygen transport to tissue: pharmacology, mathematical studies and neonatology. New York: Plenum Press, 1973, 859-862.

69. Fitts CT, James Haim Bicher, Yarborough D. Blood and tissue oxygenation during hemorragic shock as determined with ultramicro oxygen electrodes. James Haim Bicher, Bruley DF (eds). Oxygen transport to tissue: instrumentation methods and physiology. New York: Plenum Press, 1973, 447-451.

70. James Haim Bicher, Reneau D, Bruley DF, Knisely MH. Autoregulation of oxygen supply to microareas of brain tissue under bypoxic and hyperbaric conditions. Bibl Anat 1973, 11:526.

71. Reneau DD, Slack TL, Bruley DF, James Haim Bicher, Knisely MH. A systems analysis of oxygen and glucose transport in the human brain under conditions of countercurrent capillary blood flow. Bibl Anat 1973, 11:520.

72. Bruley DF, Reneau DD, Knisely MH, James Haim Bicher. Theoretical studies of brain tissue oxygenation considering the deoxygenation rate of red cells. Bibl Anat 1973, 11:507.

73. Bruley DF, James Haim Bicher, Reneau DD, Knisely MH. Autoregulation of chemotransport to brain tissue. Iberall AS, Guyton AC (eds). Regulation and control in physiological systems. Instrument Society of America, 1973, 501-502.

74. James Haim Bicher, Kuperminc M. Platelet aggregation in hyperadhesive states. Clinical Parmacol and Therap 1974, 15:604.

75. Groome L, Bruley DF, James Haim Bicher, Hunt DH. Simulating physiological systems pseudo dynamics. Summer Computer Simulation Conference. Houston, Texas, July, 1974 (Abstract).

76. James Haim Bicher. Brain oxygen autoregulation: A protective reflex to hypoxia? Microvascular Res 1974, 8:291.

77. James Haim Bicher, Padilla F, Van Wagner WH. Effect of anti-adhesive drugs on red cell sickling in vivo. Bibl Anat 1975, 13:127.

78. James Haim Bicher, Hunt DH, Flake WE, Bruley DF. Autoregulatory mechanisms controlling the supply of oxygen to microareas of brain tissue. Bibl Anat 1975, 13:137.

79. Bruley DF, Groome L, Hunt DH, James Haim Bicher. Predicting oxygen supply to brain tissue using a pseudo dynamic model simulation technique. Bibl Anat 1975, 13:139.

80. James Haim Bicher, Hunt DH, Flacke WE, Bruley DF. Autoregulatory mechanisms controlling the supply of oxygen to microareas of brain tissue. Biochemistry an Experimental Biology 1974; 75; 11:155-161.

81. Eden G, Inbar GF, Timor-Tritsch I, James Haim Bicher. Miniaturized electrodes for on-line po2 measurements. Trans Biomed Eng 1975, 22:275.

82. Bruley DF, Groome L, James Haim Bicher, Knisely MH. Stochastic modeling of the brain microcirculation. Proc of First World Congress for Microcirculation. Toronto, June, 1975 (Abstract).

83. James Haim Bicher, Bruley DF. Pharmacological control O2 autoregulation in brain tissue. Proc of First World Congress for Microcirculation. Toronto, June 1975 (Abstract).

84. James Haim Bicher, Dalrymple GC, Harris D. Effect of ionizing radiation on liver microcirculation: Suppression of O2 autoregulation as a possible coadjuvant to radiation therapy. Proc of Symp on Vascular Physiol to Tumors. Buffalo, June, 1975 (Abstract).

85. James Haim Bicher, Ashbrook D, Harris D, Dalrymple GV. Changes in platelet and microcirculation function induced by ionizing radiation to the liver. Internat J. Radiat Oncol Biol Phys 1976; 1:679-685.

86. James Haim Bicher, Marvin P. Pharmacological control of local oxygen regulation mechanisms in brain tissue. Stroke 1976, 7:469-427.

87. James Haim Bicher, Bruley DF. 13.3 pharmacological control of O2 autoregulation in brain tissue. Microcirculation 1976, 1:386-387.

88. James Haim Bicher, Marvin P, Hunt D, Bruley DF. Autonomic and pharmacological control of oxygen autoregulation mechanisms in brain tissue. Grote, Jurgen, Thews, Gerhard (eds). Oxygen transport to tissue II. New York: Plenum Press, 1977, 383-389.

89. James Haim Bicher, Dalrymple GV, Ashbrook D, Smith R, Harris D. Autonomic and pharmacological control of oxygen autoregulation mechanisms in brain tissue. Grote, Jurgen,

Thews, Gerhard (eds). Oxygen transport to tissue II. New York: Plenum Press, 1977, 497-503.

90. James Haim Bicher, Modern methodology in the study of microphysiologic functions. Experta Medica International Congress Series No. 399 Anesthesiology. (IBSN) 90 219 0327 0, 1977, 488-492.

91. Doss LL, Kaufman N, James Haim Bicher. Prevention of brain tissue hypoxia by intrathecal injection of oxygenated fluorocarbon. Microvascular Research 1977, 13:253-260.

92. James Haim Bicher, Bruley DF. Interaction of alpha adrenergic blockade and CO2 effects on the regulation of tissue O2 levels in brain. Bibl Anat 1977, 16:350-354.

93. James Haim Bicher, Kaufman N. Flow improvers prevention of microcirculation changes induced by ionizing radiation to the liver. Bibl Anat 1977, 16:341-344.

94. Doss LL, Kaufman J, James Haim Bicher. Protective effect of intrathecal fluorocarbon injection on the fall of cerebral TpO2 induced by anoxic anoxia. Bibl Anat 1977, 16:412-415.

95. James Haim Bicher, Hetzel FW, D'Agostino L, Johnson RJ. Changes in tumor tissue oxygenation induced by microwave hyperthermia. Int J. Radiat Oncol Biol Phys 1977, S-2:157.

96. Hetzel FW, James Haim Bicher, Henderson B, Johnson R. Cellular respiratory inHaim Ibitors as hypoxic cell sensitizers. Proc of the Gray Conference, Cambridge, England, 1977 (Abstract).

97. Johnson RJR, James Haim Bicher, Hetzel FW, Sandhu TS, Kowal HS. The use of either regional or whole-body hyperthermia as an adjunctive treatment with radiotherapy. Proc of Conf on Clinical Prospects of Hypoxic Cell Sensitizers and Hyperthermia, Madison, September, 1977, 324-329.

98. Hetzel FW, James Haim Bicher, Henderson BW, Kaufman N, Brown M, Mesinger M. Chemotherapeutic drugs and radiation: Sensitization by Reoxygenation. Radiat Res 1978 (Abstract).

99. Hetzel FW, James Haim Bicher, Kaufman N, Brown M, Henderson BW. Cellular respiratory inHaim Ibition by chemotherapeutic drugs as possible adjuvant to radiation therapy. Fed Proc 1978.

100. James Haim Bicher. Increase in brain tissue oxygen availability induced by localized microwave hyperthermia. Silver I, Eherecinska M, James Haim Bicher (eds). Oxygen Transport to Tissue III. New York: Plenum Press, 1978, 347-352.

101. James Haim Bicher, D'Agostino L, Doss LL, Kaufman N, Amigone J. Prevention of ionizing radiation induced by liver microcirculation changes by the use of flow improvers. Silver I, Eherecinska M, James Haim Bicher (eds). Oxygen Transport to tissue III. New York: Plenum Press, 1978, 383.

102. Bruley DF, Kreisman N, James Haim Bicher. Mathematical models for the prediction of oxygen tension and local metabolic rate in epileptic foci. Bibl Anat.1977, 16:511-515.

103. Johnson R, Sandhu TS, Hetzel FW, Song SY, James Haim Bicher, Kowal H. A pilot study to investigate skin and tumor thermal enhancement ratio of hyperthermia (41.5 - 42C) with radiation. Int J. Radiat Oncol Biol Phys 1979, 5:947-953.

104. James Haim Bicher, Hetzel FW, Mitagvaria N, O'hara M. Reoxygenation induced by localized microwave hyperthermia as an adjuvant to radiation therapy. 6th International Congress of Radiation Research, 1979, 5:171-175.

105. James Haim Bicher, Sandhu TS, Hetzel FW. Hyperthermia as a radiation adjuvant: An effective fractionation regime. Int. J. Radiat Oncol Biol Phys 1979; 171.

106. Hetzel FW, James Haim Bicher, Kaufman N, Brown M, Mensinger M. Combined chemotherapy agents and radiation: A superadditive effect. Int J. Radiat Oncol Phys 1979, 5:195.

107. James Haim Bicher, Hetzel FW, Sandhu TS. Physiological and clinical effects of microwave hyperthermia. Advances in Engineering 1979; 139.

108. Hetzel FW, James Haim Bicher, Sandhu TS, Kaufman N, Brown M. Superadditive effects in vitro combining alkylating agents and radiation. 6th International Congress of Radiation Research, 1979, 248.

109. Sandhu TS, James Haim Bicher, Hetzel FW. Realistic hyperthermia dosimetry with blood simulation. 6th International Congress of Radiation Research, 1979, 124 (abstract).

110. James Haim Bicher, Sandhu TS, Hetzel FW. Hyperthermia and radiation in combination. Int J. Radiat Oncol Biol Phys 1980, 6:867-870.

111. James Haim Bicher, Hetzel FW, Sandhu TS, Frinak S, Vaupel P, O'Hara MD, O'Brien T. Effects of hyperthermia on normal and tumor microenviroment. Radiology 1980, 137:523-530.

112. James Haim Bicher. The physiological effects of hyperthermia. Radiology; 1980:511-513.

113. Sandhu TS, James Haim Bicher, Hetzel FW. A thermal dosimetry system with blood flow simulation. Journal of National Cancer Institute, 6:361-363.

114. James Haim Bicher, Sandhu TS, Vaupel P, Hetzel FW. The effect of localized microwave hyperthermia on physiological responses. Journal of National Cancer Institute, 6:375-377.

115. Sandhu TS, James Haim Bicher, Hetzel FW. A realistic thermal dosimetry system (Meeting Abstract). THaim Ird International Symposium: Cancer Therapy by Hyperthermia, Drugs and Radiation. June 22-26, 1980, Fort Collins, Colorado. Colorado State University 1980, 152.

116. James Haim Bicher, Sandhu TS, Hetzel FW. Inhomogenities in oxygen and pH distributions in tumors. Radiat Res 1980, 83-376.

117. Hetzel FW, Kaufman N, Brown M, James Haim Bicher. Indirect sensitization by drug induced reoxygenation in spheroids. Radiat Res 1980, 83:375-376.

118. Kaufman N, Hetzel FW, James Haim Bicher. The effect of hyperthermia on oxygen distribution in spheroids. Radiat Res 1980, 83:395.

119. James Haim Bicher, Sandhu TS, Hetzel FW. Hyperthermia fractionation protocol: Preliminary results of a clinical trial. Presented at the THaim Ird International Symposium on Cancer Therapy by Hyperthermia, Drugs and Radiation. Fort Collins, Colorado, June 22-26, 1980.

120. James Haim Bicher, Sandhu TS, Vaupel P, Hetzel FW. Physiological mechanisms of action of localized microwave hyperthermia. Presented at the THaim Ird International Symposium on Cancer Therapy by Hyperthermia, Drugs and Radiation. Fort Collins, Colorado, June 19-20, 1980.

121. James Haim Bicher, Sandhu TS, Hetzel FW, Matvia F. An effective fractionation protocol for the clinical use of hyperthermia with adjuvant radiation. Presented at the Second Meeting of the European Group on Hyperthermia in Radiation. Rome, Italy, September 19-20, 1980.

122. James Haim Bicher, Sandhu TS, Hetzel FW, Matvia F. The clinical use of intracavitary antennae in the treatment of deep seated tumors with microwave induced hyperthermia. Presented at the American Society of Therapeutic Radiologists (ASTR) 22nd Annual Meeting, Dallas, Texas, October 21-25, 1980.

123. James Haim Bicher, Sandhu TS, Hetzel FW. Fractionated hyperthermia in combination with radiation: Clinical results. Presented at (ASTR) 22nd Annual Meeting, Dallas, Texas, October 21-25, 1980.

124. Hetzel FW, Kaufman N, James Haim Bicher. Oxygen distribution in spheroids: Effects of hyperthermia and drugs. Presented at the (ASTR) 22nd Annual Meeting, Dallas, Texas, October 21-25, 1980.

125. Kaufman N, James Haim Bicher, Hetzel FW. A system for studying spheroid microphysiology. Presented at the International Workshop/Conference on Spheroids in Cancer Research, Rochester, New York, June 16-20, 1980.

126. Kaufman N, James Haim Bicher, Hetzel FW. Measuring pO2 in spheroids during hyperthermia. Presented at the International Workshop/ Conference on Spheroids in Cancer Research. Rochester, New York, June 16-20, 1980.

127. Kaufman N, James Haim Bicher, Hetzel FW, Brown M. A system for determining the pharmacology of indirect radiation sensitizer drug on multicellular spheroids. Cancer Clinical Trials 1981; IV: 199-204.

128. James Haim Bicher, Vaupel P, O'Hara MD, O'Brien T, Mitagvaria N. Tissue oxygenation in normal and hyperthermic conditions. In proceedings of the XXVIIIth International Congress of Physiological Sciences. Budapest, Hungary, July 13-18, 1980. Akademial Kiado Publishers: Adv. Physiol Sci. 1981, 25:215-233.

129. Hetzel FW, Brown M, Kaufman N, James Haim Bicher. Radiation sensitivity modification by chemotherapeutic agents. Cancer Clinical Trials 1981, IV:177-182.

130. James Haim Bicher, Hetzel FW, Vaupel P, Sandhu TS. Microcirculation modification by localized microwave hyperthermia and hematoporphyrin phototherapy. Bibl Anat 1981, 20:628-632.

131. James Haim Bicher, Sandhu TS, Hetzel FW. Clinical thermoradiotherapy Henry Ford Hospital Med. J. 1981, 29:9-15.

132. James Haim Bicher, Mitagvaria N. Circulatory responses of malignant tumors during hyperthermia. Microvascular Research 1981, 21:19-26.

133. James Haim Bicher. Status of ongoing clinical trials with microwave hyperthermia. Brit J. Cancer 1982, 45:247-248.

134. James Haim Bicher. Hyperthermia, clinical results. In progress in Radio-Oncolgy II. 409-413 (ed). K.H. Karcher, Raven Press, New York, 1982.

135. James Haim Bicher, Hetzel FW, Sandhu TS. Results of a phase I/II clinical trial of fractionated hyperthermia in combination with low dose ionizing radiation. Adv Exp Med Biol 1982, 157:87-97.

136. Busch NA, Bruley DF, James Haim Bicher. Computer modeling of tumor hyperthermia (a dynamic lumped parameter model). Adv Exp Med Biol 1982, 157:185-189.

137. Busch NA, Bruley DF, James Haim Bicher. Identification of viable regions in "in vivo" spheroidal tumors: a mathematical investigations. Adv Exp Med Biol 1982, 157:1-7.

138. James Haim Bicher, Sandhu TS, Vaupel P, Hetzel FW. Effect of localized microwave hyperthermia on physiological responses. Natl Inst Drug Abuse Res Monogr Ser 1982, 61:217-219.

139. Vaupel P, Frinak S, Mueller-Klieser W, James Haim Bicher. Impact of localized hyperthermia on the cellular microenvironment in solid tumors. Natl Inst Drug Abuse Res Monogr Ser 1982, 61:207-209.

140. James Haim Bicher, Hetzel FW, Sandhu TS. Results of phase I/II clinical trial of fractionated hyperthermia in combination with low dose ionizing radiation. Advances in Experimental Medicine and Biology, 157: 87-97, 1983.

141. James Haim Bicher, Fingerhut AG, Frey HS, Lewinsky BS, Metcalf D, Syed N. A method of interstitial thermoradiotherapy. (Meeting Abstract). Fift Mid-Winter Meeting of the American Endocurietherapy Society, December 8-10, 1982, Key Biscayne, Florida. American Endocurietherapy Society; 50, 1982.

142. James Haim Bicher, Fingerhut AG, Frey HS, Lewinsky BS, Metcalf D. A system for hyperthermia retreatment of radiation failures in a free standing radiation therapy center. (Meeting abstract). THaim Irty-First Annual Meeting of the Radiation Research Society, February 27 - March 3, 1983, San Antonio, Texas, Radiation Research, 145, 1983.

143. James Haim Bicher, Metcalf DR, Frey HS, Lewinsky BS, Fingerhut AG, Bruley DF. Comparative thermometry studies using microthermocouples and optic probes. The microcirculation factor (Meeting abstract). THaim Irty-First Annual Meeting of the Radiation Research Society, February 27-March 3, 1983, San Antonio, Texas. Radiation Research, 145, 1983.

144. Gonzalez-Vazquez HE, Bruley DF, James Haim Bicher. Distributed parameter model of temperature gradients in tumor tissue during hyperthermia with uniform heat source and nonuniform blood flow. (Meeting abstract). THaim Irty-First Annual Meeting of the Radiation Research Society, February 27-March 3, 1983, San Antonio, Texas. Radiation Research, 145, 1983.

145. Henderson BW, James Haim Bicher, Johnson RF. Loss of vascular fibrinolytic activity following irradiation of the liver - An aspect of late radiation damage. Radiation Research, 95:646-652, 1983.

146. James Haim Bicher. Impact of microcirculation and physiologic considerations on clinical hyperthermia. Proceedings 13th International Cancer Congress, 235-245, Alan R Liss Inc., New York, 1983.

147. James Haim Bicher. The set-up of state of the art hyperthermia clinic-therapeutic, etHaim Ical and practical considerations. Frontiers in Radiation Therapy Oncology, 18:153-161;1984.

148. James Haim Bicher, Wolfstein RS. Microwave hyperthermia as an adjuvant to radiation therapy. Summary experience of 208 multifraction treatment cases. Proceedings of the 4th International Symposium on Hyperthermic Oncology, Taylor and Francis LTD, London and PHaim IladelpHaim Ia, 1:363-366, 1984.

149. James Haim Bicher, Wolfstein RS, Fingerhut AG, Frey HS, Lewinsky BS. An effective fractionation regime for interstitial thermoradiotherapy. Preliminary clinical results. Proceedings of the 4th International Symposium on Hyperthermic Oncology, Taylor and Francis LTD, London and PHaim IladelpHaim Ia, 1:575-578, 1984.

150. James Haim Bicher, Wolfstein RS, Fingerhut AG, Lewinsky BS, Frey HS. Clinical multified controlled comparison of the hyperthermia and low dose radiation to full dose radiation of chest wall recur rence. Proceedings of the 4th International Symposium on Hyperthermic Oncology, Taylor and Francis LTD, London and PHaim IladelpHaim Ia, 1:391-394, 1984.

151. James Haim Bicher, Mitagvaria NP. Changes in tumor tissue oxygenation during microwave hyperthermia clinical relevance. Proceedings of the 4th International Symposium on Hyperthermic Oncology, Taylor and Francis LTD, London and PHaim IladelpHaim Ia, 1:169-172, 1984.

152. James Haim Bicher, Moore DW, Wolfstein RS. A method for interstitial thermoradiotherapy. Proceedings of the 4th International Symposium on Hyperthermic Oncology, Taylor and Francis LTD, London and PHaim IladelpHaim Ia, 1:595-598, 1984.

153. Afuwape SA, Bruley DF, James Haim Bicher. Parameter identification of silastic tumor-analog during thermometry control experience in hyperthermia. (Meeting abstract) 4th North American Hyperthermia Group, March 23-27, 1984, Orlando, Florida.

154. Gonzalez-Vasquez HE, Bruley DF, James Haim Bicher. Three dimensional reconstruction of temperature profiles in tumor phantoms. (Abstract) 4th North American Hyperthermia Group, March 23-27, 1984, Orlando, Florida.

155. James Haim Bicher, Dujovny H, Codas C, Honig S. Effect of DMSO and barbiturates on brain oxygen distribution. Oxygen transport to tissue, Vol V, edited by D.W. Lubbers, H. Acker, E. Leniger- Follert, and TK Goldstick. Plenum Press, 1984, 180:332-387.

156. James Haim Bicher. Hyperthermia, radiation and cancer microenvironment. (Meeting Abstract). 1983 International Society on Oxygen Transport to Tissue Meeting, August 16-19, 1983, Ruston Louisiana.

157. James Haim Bicher, Mitagvaria NP. Changes in tumor tissue oxygenation during microwave hyperthermia clinical relevance. Advances in Experimental Medicine and Biology, 180: 190-905, 1985.

158. Mitagvaria NP, James Haim Bicher. Effect of microwave radiation on local blood flow and tissue oxygenation in the brain. Bulletin of Experimental Biology and Medicine, 98:895-897, 1984.

159. James Haim Bicher, Moore DW, Wolfstein RS. Air-cooled 300MHz applicators used in a parallel opposed phase system (POPAS). Int. J. Radiat Oncol Biol Phys, 11:S-1:217, 1985.

160. James Haim Bicher, Wolfstein RS, Moore DW. A method for Interstitial thermoradiotherapy preliminary clinical results. Endocurie, Hyperthermia Oncology, 1:136, 1985. (Abstract).

161. James Haim Bicher, Wolfstein RS. Local hyperthermia for deep tumors, experience with three techniques. J. Microwave Power 1986; 21st International Microwave Power Symposium Summaries:103.

162. James Haim Bicher, Wolfstein RS, Lewinsky BS, Frey HS, Fingerhut AG. Microwave hyperthermia an adjunct to radiation therapy: Summary experience of 256 multifraction treatment cses. Int J Rad Onc Biol Phys 1986, 12:1667-1671.

163. James Haim Bicher, Afuwape SA, Bruley DF. A Three dimensional axisymetrical finite element method (FEM) of microwave energy deposition in biological media. (Abst.) 7th Annual Meeting, North American Hyperthermia Group, February 21-26, 1987.

164. Kang KA, Bruley DF, James Haim Bicher. A computer simulation of simultaneous heat and oxygen transport during heterogeneous three dimensional tumor hyperthermia. Adv. Exp. Med. Biol. 1987, 3:455-451..

165. James Haim Bicher, Shani J, Reesman KJ. Use of non perturbing thermocouples (NPT's) for hyperthermia clinical thermometry. Int. J. Hyperthermia, 3:550-551, 1987. (Abst) and J. Microwave power 22: 173, 1987, (Abst).

166. James Haim Bicher, Wolfstein RS, Chatham PL. Hyperthermic adjunct treatment for specific sites: nasopharynx, pancreas, liver, chest and pelvis. Preliminary experience. Int. J. Hyperthermia 3:551, 1987 (Abstract).

167. James Haim Bicher, Afuwape SA. Mathematical prediction and phantom studies of the clinical target "Hot spot" using a three applicator phased array system (TRIPAS). Int. J. Hyperthermia 3:550, 1987 (Abstract).

168. James Haim Bicher, Afuwape SA, Bruley DF. Reesman KJ, Wolfstein RS. Mathematical prediction and phantom studies of the clinical "Hot spot" using a three applicator phased array system (TRIPAS). Amer. Soc. Mech. Eng. Symposium on Hyperthermia, December 13-18, 1987.

169. James Haim Bicher, Afuwape SA. A three applicator microwave phased array system (TRIPAS). Featuring mathematical prediction and relocation of the hyperthermia clinical target "Hot spot". J. Microwave Power, 22:173-178, 1987.

170. James Haim Bicher, Wolfstein RS. Local Hyperthermia of tumors at moderate depth using POPAS: Results by site (Abstract). 36th Annual Meeting of the Radiation Research Society, 4:16-21, 1988.

171. James Haim Bicher, Shani J, Reesman KJ. Use of non-perturbing thermocouple for clinical hyperthermia thermometry (Abstract). 36th Annual Meeting of the Radiation Research Society, 4:16-21, 1988.

172. James Haim Bicher, Wolfstein RS. Treatment of intratoracic lesions. Preliminary results (Abstract). 37th Annual Meeting of the Radiation Research Society. 3:18-23, 1989.

173. James Haim Bicher, Reesman KJ. Use of conductive thermoplastic wires as oxygen sensors in microwave fields (Abstract). 37th Annual Meeting of the Radiation Research Society, 3:18-23, 1989.

174. James Haim Bicher, Wolfstein RS. Hyperthermia treatment for abdominal tumors (Abstract). 37th Annual Meeting of the Radiation Research Society, 3:18-23, 1989.

175. James Haim Bicher, Wolfstein RS. Local superficial and deep hyperthermia. Factors affecting tumor response and patient survival (Abstract). 37th Annual Meeting of the Radiation Research Society, 3:18-23, 1989.

176. James Haim Bicher, Reesman KJ, Afuwape SA. A target triapplicator system with non-perturbing thermocouples thermometry. Hyperthermic Oncology 1988, Taylor and Francis, 1:778-779, 1989.

177. James Haim Bicher, Wolfstein RS. Hyperthermia palliation of bone pain (Abstract). The 13th International Symposium on Clinical Hyperthermia, 5:21-25, 1990.

178. James Haim Bicher, Haim Ileman D, Moore D, Caridad C. Use of Pi-Network tuners in non-contact hyperthermia applicators (Abstract). The 13th International Symposium on Clinical Hyperthermia 5/21-25, 1990.

179. James Haim Bicher, Wolfstein RS. More treatments prove better thermotolerance ? (Abstract). 11th Conference of the European Society for Hyperthermia Oncology, 9:17-20, 1990.

180. James Haim Bicher, Wolfstein RS. Clinical use of regional hyperthermia. Adv in Exp Med and Biol. Plenum Press, New York, 267: 1-20, 1990.

181. James Haim Bicher, Afuwape SA, Wolfstein RS, Bruley D, Reesman K. Tripas: A triple applicator system with relocatable "Hot spot" at tissue depth. Adv in Exp Med and Biol. Plenum Press, New York, 267: 327-344, 1990.

182. James Haim Bicher, Wolfstein RS. Local hyperthermia for superficial and moderately deep tumors. Factors affecting response. Adv in Exp Med and Biol. Plenum Press, New York, 267: 353-367, 1990.

183. James Haim Bicher, Wolfstein RS. Local hyperthermia for deep tumors. Adv in Exp Med and Biol. Plenum Press, New York, 267:411-422, 1990.

184. James Haim Bicher,Lung paper? (Abstract). Proceeding of the 14th International Symposium on Clinical Hyperthermia (ICHS), Dubna, USSR, May 20-24, 1991.

185. James Haim Bicher, Wolfstein RS. Local Hyperthermic Treatment for Cancer in Aids Patients (Abstract). Proceeding of the 9th International Congress of Radiation Research (ICRR). Toronto, Canada, July 7-12, 1991.

186. James Haim Bicher, Mitagvaria, N. Oxygen and pH in Human Tumors During Hyperthermia (Abstract). Proceeding of the 1991 International Society on Oxygen Transport to Tissue Meeting (ISSOT). Willemstad, Curaco, Netherlands Antilles, August 24-30, 1991.

187. Mitagvaria, N., James Haim Bicher. Local Blood Flow and PO2 in Rat's Brain During Maze Behavior (Abstract). Proceeding of the 1991 International Society on Oxygen Transport to Tissue Meeting (ISSOT). Willemstad, Curaco, Netherlands Antilles, August 24-30, 1991.

188. James Haim Bicher, Wolfstein RS. Transcranial Treatment of Brain Tumors with Microwave Hyperthermia (Abstract). Proceeding of the 8th Annual Conference of the American Society for Clinical Hyperthermic Oncology (ASCHO). CHaim Icago, Illinois, October 31-November 2, 1991.

189. James Haim Bicher, Wolfstein RS. Direct Relation Between Thermal Dose and Tumor Response in Hyperthermia Therapy (Abstract). Proceeding of the 77th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA).CHaim Icago, Illinois. December 1-6, 1991.

190. James Haim Bicher, Mitagvaria N. Oxygen and pH in Human Tumors During Hyperthermia (Paper presented as a poster). Proceeding of the 6th International Congress on Hyperthermic Oncology. Tucson, Arizona, April 26- May 1, 1992.

191. James Haim Bicher, Mitagvaria N. Oxygen and pH in Human Tumors During Hyperthermia (Abstract). Proceeding of the XV International Symposium on Clinical Hyperthermia (ICHS). Lyon, France, May 19-22, 1992.

192. James Haim Bicher, Wolfstein RS. Hyperthermia for Deep Tumors Analysis of Six Years Experience (Abstract). Proceeding of the 9th Annual Meeting of the American Society of Clinical Hyperthermic Oncology (ASCHO). Los Angeles, California, November 5-8, 1992.

193. Surowiec, A. James Haim Bicher, Evaluation of Multiplane Sar Distribution of Hyperthermia Applicators by Means of Liquid-Crystal Card and Polyacrylamide Phantom System (Abstract). Proceeding of the 9th Annual Meeting of the American Society of Clinical Hyperthermic Oncology (ASCHO). Los Angeles, California, November 5-8, 1992.

194. Surowiec, A. James Haim Bicher, Caridad, C. Vinh, F. Heating Characteristics of Tripas Systems (Abstract). Proceeding of the 9th Annual Meeting of the American Society of Clinical Hyperthermic Oncology (ASCHO). Los Angeles, California, November 5-8, 1992.

195. James Haim Bicher, Update on Hyperthermia Clinical Trials (Abstract). Proceeding of the 9th Annual Meeting of the American Society of Clinical Hyperthermic Oncology (ASCHO). Los Angeles, California, November 5-8, 1992.

196. James Haim Bicher, Yarmonenko S. Wainson A. Surowiec I. Metagvaria N. Specific InHaim Ibition of L-Glucose Cell Proliferation. Potentiation of Hyperthermia, Radiation, and Chemotherapy Effects (Abstract). Proceeding of the 16th International Symposium on Clinical Hyperthermia (ISCH). Kyoto, Japan, June 13-16, 1993.

197. Surowiec, A. James Haim Bicher, Caridad, C. A Comparison of Heating Characteristics of Two Hyperthermia Systems Used for Deep Seated Malignancies BSD-2000 and Tripas (Abstract). Proceeding of the 16th International Symposium on Clinical Hyperthermia (ISCHO). Kyoto, Japan, June 13-16, 1993.

198. James Haim Bicher, Yarmonenko S, Wainson A, Swrowiec I, Metagvaria N. Specific inHaim Ibition of L-Glucose cell proliferation. Potentiation of Hyperthermia, Radiation and Chemotherapy effects (Abstract). Proceeding of the 10th Annual Meeting of the American Society Of Clinical Hyperthermic Oncology (ASCHO). MempHaim Is, Tennessee; November 28-30, 1993.

199. James Haim Bicher, Yarmonenko S, Mescherikova V, Strunina I, Wainson A.The modifying effect of L-Glucose on thermal damage of malignant cells (Abstract). Proceeding of the 10th Annual Meeting of the American Society Of Clinical Hyperthermic Oncology (ASCHO). MempHaim Is, Tennessee, 10:28-30, 1993.

200. James Haim Bicher, Yarmonenko S, Wainson A, Surowiec I, Mitagvaria N. Specific InHaim Ibition of L-Glucose on Cancer Cell Proliferation Potentiation of Hyperthermia, Radiation and Chemotherapy Effects(Abstract). Proceeding of the 14th Annual Meeting of the North American Hyperthermia Society (NAHS), Nashville, Tennessee, April 29 - May 4, 1994.

201. Surowiec, A, James Haim Bicher, Intercomparison of Heating Patterns of the BSD-2000 and the Tripas System (Abstract). Proceeding of the 14th Annual Meeting of the North American Hyperthermia Society (NAHS), Nashville, Tennessee, April 29- May 4, 1994.

202. James Haim Bicher, Yarmonenko, S. Wainson, A. Surowiec, I. Mitagvaria, N. Anticancer Effect of L-Glucose In-Vivo Potentiation of Hyperthermia (Abstract). Proceeding of the 17th International Symposium on Clinical Hyperthermia (ISCH). Pavia, Italy,

May 1-5, 1994.

203. James Haim Bicher, Surowiec, A. Heating Characteristics of the Tripas Hyperthermia System for deep Seated Malignancy. Publicacion May 13, 1995 International Microwave Power Institute.

204. James Haim Bicher, Wolfstein, R.S. Hyperthermia for Visceral Tumors. Radiation Research Society.

Annual Meeting, 1989.

205. James Haim Bicher, Bruley, D. F. Changes in tissue oxygenation and Acidity induced by localized Microwave Hyperthermia and Hematoporphyrin Phototherapy, an Update*. From OXYGEN TRANSPORT TO TISSUE –IV.

206. James Haim Bicher, Wolfstein, RS, Burmistrovich, B. Tressia, K. Thermoradiotherapy for Prostate Cancer. Hyperthermic Oncology 1996. Volume II. Proceedings of the 7th International Congress on Hyperthermia Oncology Roma, Italy April 9-13 1996.

207. James Haim Bicher, Wolfstein, RS., Tressia Keen M.N., Sylvia Carter Ph. D. Thermoradiotherapy Treatment for Localized Inflammatory Breast Cancer. April 26-29, 2000 Kyongju, Korea

208. James Haim Bicher, Wolfstein, RS. MD., Boris Boris Burmistrovich MD., Tressia Keen, MN. Effect of Tumor Stage and Frequency of treatment on local response to Thermoradiotheraphy. Proceedings of the 7th. ICHO. Roma, Italy. April 9-13, 1996

209. James Haim Bicher, Wolfstein, RS MD., Keen, T., MN, Carter, S., PHD. Thermoradiotherapy in breast cancer-the treatment of localized inflammatory recurrence. Proceedings of the twenty Second meeting of the International Clinical Hyperthermia Society, Marina del rey, California USA. From September 23rd – 25th , 1999

210. James Haim Bicher. MD. Thermoradiotherapy Fractionation in the Clinical treatment of malignant tumors. Proceedings of the twenty second meeting of the International Clinical Hyperthermia Society. Marina del Rey, California USA. From September 23rd- 25th , 1999.

211. James Haim Bicher. MD.,Wolfstein, RS. MD.,Tressia Keen, M.N., Sylvia Carter, Ph.D. An Update on the treatment of localized inflammatory breast cancer recurrence. Valley Cancer Institute, Los Angeles, California. USA. Proceedings of the twenty THaim Ird meeting of the ICHO. Lyon France. June 15-17, 2000.

212. James Haim Bicher MD., Eva H. Barker, Patrick J. Bolan, Lance delabarre, Hellmuth Merkle, Lenore I. Everson, Michael Garwood. In VIVO Monitoring to Treatment for Breast Cancer Using 4T H MRS. Center for Magnetic Resonance Research, University of Minnesota, 2021 Sixth street SE, Minneapolis, MN. USA;

213. James Haim Bicher MD.; Wolfstein, RS. M.D.; Tressia Keen M.N. and Silvia, Carter RTT. Low Dose Hyperfractioned Thermoradiotherapy in the Clinical Treatment of Malignant Tumors. . Proceedings of the 18th Annual Meeting N.A.H.S. in PHaim IladelpHaim Ia, Pensylvania. USA. April 8-10, 1999.

214. James Haim Bicher MD.; Wolfstein, RS. M.D. Thermoradiotherapy Treatment for prostate cancer-an update.Proceedings of the 48th RRS / 18TH N.A.H.S. in San Juan, Puerto Rico. April 21st-25th, 2001.

215. James Haim Bicher MD.; Wolfstein, RS. M.D.; Tressia Keen M.N. and Sylvia, Carter RTT. Thermoradiotherapy in breast cancer-The treatment of localized inflammatory recurrence. Proceedings of the ESHO, Verona, Italy, May 30th-June 2nd, 2001.

216. James Haim Bicher MD. Thermoradiotherapy Treatment of malignant tumors. Fractionation regime and objective end points. Proceedings of the XXIV ICHS Rome-Pavia, Italy September 24th-29th, 2001.

217. James Haim Bicher MD.; Wolfstein, RS. M.D.; Tressia Keen M.N. and Sylvia, Carter RTT.; and Garwood, Michael. Ph.D. Thermoradiotherapy in Breast cancer. Treating with curative intent and objective end point parameters. Proceedings of the XXIV ICHS Rome- Pavia, Italy September 24th-29th, 2001.

218. James Haim Bicher MD.; Wolfstein, RS. M.D.; Tressia Keen M.N. and Sylvia, Carter RTT.; and Garwood, Michael. Ph.D. Thermoradiotherapy in Breast cancer. Treating with curative intent and objective end point parameters. Proceedings of the 49th Radiation Research Society, 20th NAHS, Reno, Nevada, USA. April 20th-24th, 2002.

219. James Haim Bicher MD. Protracted Thermoradiotherapy, treating to effect with objective end points. Proceedings of the XXV ICHS Destin, Florida, USA, October 16th-19th, 2002

220. James Haim Bicher MD, Mitagvaria NP PhD, Nebieridze MI MD. Local Hyperthermia treatment results in significant morphological changes in rats’ brain tissue. Proceedings of the XXVI ICHS Shenzhen, CHaim Ina, September 10th-12th, 2004.

221. James Haim Bicher MD. Thermoradiotherapy Treatment of malignant tumors. Fractionation regime and objective end points. An update. Proceedings of the XXVI ICHS Shenzhen, CHaim Ina, September 10th-12th, 2004.

James Haim Bicher MD., Al-Bussam N MD; Wolfstein, RS. M.D Thermoradiotherapy with curative intent – breast, head and neck and prostate tumors. Proceedings of the XXVII ICHS Florence, Italy, October 27th – 28th, 2005.

James Haim Bicher MD., Al-Bussam N MD; Wolfstein, RS. M.D Thermoradiotherapy with curative intent – breast, head and neck and prostate tumors. Deutsche Zeitschrift für Onkologie (German Journal of Oncology) 2006, 38: 116-122.

 

EXHaim IBITS

 

1. James Haim Bicher, Sandhu TS, Hetzel FW. Clinical hyperthermia: New scientific rationals, new technology, clinical results. (ASTR) 22nd Annual Meeting, Dallas, Texas, October 21-25, 1980.

2. James Haim Bicher, Fingerhut AG, Frey HS, Lewinsky BS, Metcalf DR. A system for hyperthermia retreatment of radiation failures in a free standing radiation therapy center. (Meeting Abstract). THaim Irty-First Annual Meeting of the Radiation Research Society, February 27 - March 3, 1983, San Antonio, Texas. Radiation Research Society, 1983.

Valley Cancer Institute. Dr. Haim Bicher received an award in India.

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Haim Bicher, President of Valley Cancer Institute. Dr. Haim Bicher received an award in India.